This painting delves into the ATAC-seq technique, crucial for identifying open chromatin regions in DNA. The submerged, tightly-wound chromatin in the water represents inaccessible DNA regions. Rising above, the mountains symbolize peaks of enriched open chromatin, uncovered through sequencing and peak-calling processes. Clouds in the sky depict the Tn5 transposase, essential for binding and cutting open chromatin, enabling its isolation, amplification, and sequencing. This visual metaphor captures the journey of chromatin accessibility mapping, illustrating how these regions serve as potential binding sites for gene regulatory proteins such as transcription factors. The artwork merges molecular biology and bioinformatics, transforming scientific discovery into a natural landscape.
